Earlier today I commented on my optimism concerning closed-loop control for glucose management. A different application but somewhat analagous system (i.e., closed-loop) has been developed and tested for anesthesia delivery:
We have developed a proportional-integral-derivative controller allowing the closed-loop coadministration of propofol and remifentanil, guided by a Bispectral Index (BIS) monitor, during induction and maintenance of general anesthesia. The controller was compared with manual target-controlled infusion.
The controller allows the automated delivery of propofol and remifentanil and maintains BIS values in predetermined boundaries during general anesthesia better than manual administration.
You can see the system in action below (video uploaded by Medgadget):